Reports of Pathological Gambling, Hypersexuality, and Compulsive Shopping Associated With Dopamine Receptor Agonist Drugs

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Reports of pathological gambling, hypersexuality, and compulsive shopping associated with dopamine receptor agonist drugs.

IMPORTANCE Severe impulse control disorders involving pathological gambling, hypersexuality, and compulsive shopping have been reported in association with the use of dopamine receptor agonist drugs in case series and retrospective patient surveys. These agents are used to treat Parkinson disease, restless leg syndrome, and hyperprolactinemia. OBJECTIVES To analyze serious adverse drug event ...

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Detecting associations between behavioral addictions and dopamine agonists in the Food & Drug Administration’s Adverse Event database

BACKGROUND/AIMS Studies have reported higher prevalences of four behavioral addictions (binge eating, compulsive shopping, hypersexuality, and pathological gambling) in dopamine agonist-treated Parkinson's disease relative to non-dopamine agonist-treated Parkinson's. However, recent case-control and epidemiological studies suggest that prevalences of behavioral addictions in dopamine agonist-tr...

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Is dopamine agonist therapy associated with developing pathological gambling in Parkinson's disease patients?

In recent years, improving the quality of life and the level of functioning in Parkinson's disease patients has become the main challenge of all therapeutic protocols for this chronic disease. Hence, identifying comorbid psychiatric conditions is the ambition of many studies in the field. To date, a few research studies have investigated the development of problem gambling as a potential side e...

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Pathological Gambling Associated With Aripiprazole or Dopamine Replacement Therapy

BACKGROUND In the last 10 years, dopamine replacement therapy (DRT) has become a well-known risk factor for developing an impulse control disorder, such as gambling disorder (GD). Another medication, aripiprazole (ARI), has been more recently identified as another risk factor. Dopamine replacement therapy and ARI share a dopamine agonist action. Our work aimed at comparing patients with PG acco...

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Pathological gambling and dopamine agonists: A phenotype?

Pathological gambling and dopamine agonists: A phenotype? Therapeutic dopamine agonists have been around a long time ever since the defi cit of brain dopamine in Parkinson’s disease (PD) was fi rst reported in 1960 (Ehringer and Hornykiewicz 1960) swiftly followed by the fi rst clinical trial of levodopa administration in Parkinsonian patients (Birkmayer and Hornykiewicz 1961). Design of new do...

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ژورنال

عنوان ژورنال: JAMA Internal Medicine

سال: 2014

ISSN: 2168-6106

DOI: 10.1001/jamainternmed.2014.5262